Lives unaffected by cystic fibrosis

Clinical Trial Finder

Be a part of the movement transforming the future of cystic fibrosis treatment.

Clinical trials are listed below.

  • Mucociliary ClearanceRecruiting Location: Sir Charles Gairdner Hospital, Perth, WA

    Does the MetaNeb®, a new airway clearance device, change lung function in adults with cystic fibrosis when they are hospitalised for a lung infection? , protocol number ACTRN12619001681145

    This project will look at the effects of twice daily treatment using a new airway clearance device called the MetaNeb®, on lung function, secretion clearance and CF related symptoms compared to twice daily treatment using ACT in adults with CF who are hospitalised with a respiratory exacerbation. We hypothesise that in adults with CF, hospitalised with a respiratory exacerbation, twice daily MetaNeb® treatment, compared with usual ACT, will produce greater improvements in lung function, secretion clearance, health-related quality of life (HRQoL) and respiratory signs and symptoms. If this device is shown to be more effective than the commonly used techniques, this would be of great clinical significance as it will assist in guiding clinical use of the device throughout CF centres in Australia and internationally.

    • Age:

      18 Years and Older

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      Not specified

    • Length of Participation:

      Not specified

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  • OtherRecruiting Location: Queensland Children's Hospital, Brisbane

    Implementing a comprehensive adherence protocol for children and adolescents living with cystic fibrosis - an implementation study , protocol number ACTRN12619001730190

    The primary aim of this project is to evaluate the feasibility, acceptability and appropriateness of implementing a comprehensive adherence protocol into the Queensland Children's Hospital Cystic Fibrosis clinic.

    • Age:

      8 Years and 18

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      Not specified

    • Length of Participation:

      Not specified

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  • OtherRecruiting Location: Royal Prince Alfred Hospital, NSW

    Cystic Fibrosis Telehealth Virtual Clinic Initiative , protocol number ACTRN12620000084987

    This study will evaluate an updated health care delivery model for patients with cystic fibrosis by incorporating virtual health/telehealth clinics. For patients in the telehealth arm, clinic visits may occur at home, work or at their local GP practice. This will replace in-hospital clinic visits. Patients in this arm however will need to attend at least one in-hospital clinic visit over a 12 months period. Spirometry will be performed at home using a portable spirometer. Patient satisfaction and well-being questionnaires will need to be completed at baseline, 6 and 12 months.

    • Age:

      16 Years and Older

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      1

    • Length of Participation:

      12 months

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  • Anti-InfectiveEnrolling Location: Vancouver, Calgary, Toronto

    A phase 3 study on the use of prednisone in cystic fibrosis pulmonary exacerbations (PIPE) , protocol number PIPE NCT03070522

    To evaluate the effectiveness of prednisone as an adjunctive treatment for patients who do not respond to regular IV antibiotics

    • Age:

      6+

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      Not specified

    • Length of Participation:

      3 years

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  • Restore CFTR FunctionClosed to enrollment Location: Toronto

    A phase 3 rollover study of VX-659 triple combination drug in people 12 years and older who have one copy of the F508del mutation and one copy of a minimal function mutation (VX-659-105) , protocol number VX-659-105 NCT03447262

    CFTR function study evaluating the long term safety and efficacy of VX-659 combination therapy

    • Age:

      12+

    • Mutation(s):

      One copy F508del

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      Not specified

    • Length of Participation:

      96 weeks

    Contact us about this clinical Trial >
  • Restore CFTR FunctionClosed to enrollment Location: Vancouver, Montreal, Toronto

    A phase 3 study of tazacaftor (VX-661) combination drug in children aged 6 years and older (VX17-661-116) , protocol number VX17-661-116) NCT03537651

    CFTR function study, evaluating the safety and efficacy of long-term treatment with tezacaftor in combination with ivacaftor in subjects aged 6-11 years

    • Age:

      6+

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      Not specified

    • Length of Participation:

      96 weeks

    Contact us about this clinical Trial >
  • Restore CFTR FunctionClosed to enrollment Location: Vancouver, Montreal, Toronto

    A phase 3 rollover study of VX-445 triple combination drug in people 12 years and older who have one copy of the F508del mutation and one copy of a minimal function mutation (VX17-445-105) , protocol number VX17-445-105 NCT03525574

    CFTR function study, evaluating the long-term effectiveness, safety, and effect on the body of the drug VX-445 in combination with tezacaftor and ivacaftor

    • Age:

      12+

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      One copy F508del

    • Number of Visits:

      Not specified

    • Length of Participation:

      96 weeks

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  • Restore CFTR FunctionEnrolling Location: Toronto

    A phase 3 open-label extension study in people 12 years and older (VX-18-445-113) , protocol number VX 18-445-113 NCT04043806

    This study will evaluate the long term safety and tolerability of elexacaftor (ELX, VX-445) in triple combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA).

    • Age:

      12+

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      Not specified

    • Length of Participation:

      100 weeks

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  • Restore CFTR FunctionClosed to enrollment Location: Montreal, Toronto and Vancouver

    A phase 3 rollover study evaluating the long-term safety and efficacy of VX-445 triple combination therapy (VX18-445-110) , protocol number VX-445-100 NCT04058366

    This study will evaluate the long-term safety, efficacy and pharmacodynamics of elexacaftor (ELX, VX-445) in triple combination (TC) with texacaftor (TEX) and ivacaftor (IVA) in subjects with cystic fibrosis (CF) who are heterozygous for the F508del mutation and a gating or residual function mutation (F/G and F/RF genotypes).

    • Age:

      12+

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      Not specified

    • Length of Participation:

      96 weeks

    Contact us about this clinical Trial >
  • Restore CFTR FunctionClosed to enrollment Location: Vancouver & Toronto

    A phase 3 rollover study evaluating the long-term safety and efficacy of VX-445 combination therapy in subjects with cystic fibrosis who are 6 years of age and older (VX 18-445-107) , protocol number VX 18-445-107 NCT04183790

    This study will evaluate the long-term safety, tolerability, efficacy and pharmacodynamics of elexacaftor (ELX, VX-445) in triple combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in subjects with cystic fibrosis (CF).

    • Age:

      6+

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      Not specified

    • Length of Participation:

      96 weeks

    Contact us about this clinical Trial >
  • Displaying results 1-10 (of 191)
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