Lives unaffected by cystic fibrosis

Clinical Trial Finder

Be a part of the movement transforming the future of cystic fibrosis treatment.

Clinical trials are listed below.

  • OtherEnrolling Location: Australia

    Continuous infusion antipseudomonal betalactams versus standard short infusions in the treatment of acute infective exacerbations in patients with cystic fibrosis - impact on clinical and microbiological outcomes. , protocol number NCT01667094 ACTRN12612000945820

    Cystic fibrosis (CF) is an inherited disorder which results in increased thickness of secretions, especially in the lungs. By adulthood, the majority of patients with CF will have bacteria living in their lungs, called Pseudomonas which can cause lung infections. This usually results in worsening respiratory symptoms and often an acute deterioration in their lung function. They are usually treated with antibiotics that target the Pseudomonas aeruginosa. These antibiotics are typically given as short intravenous infusions several times a day. This study aims to compare the standard method of giving these antibiotics with a different strategy of giving these antibiotics to see if this can improve the outcomes of treatment of these infections and reduce the amount of Pseudomonas aeruginosa in the lungs of these patients. This strategy consists of giving the same antibiotics continuously, to ensure there is always enough antibiotic in the bloodstream and the lung to be able to kill the bacteria.

    • Age:

      18 Years and Older

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      0

    • Length of Participation:

      Not specified

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  • OtherEnrolling Location: Australia

    Does vibration training improve muscle power, bone strength and physical function in children and adolescents with cystic fibrosis. , protocol number ACTRN12609000520235

    A study to examine th effects of home based whole body vibration training on increasing muscle in children 6-18 years.

    • Age:

      6 - 18 years

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      > 25%

    • Number of Visits:

      Not specified

    • Length of Participation:

      Not Specified

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  • Restore CFTR FunctionClosed to enrollment Location: Australia

    An open-label, rollover study to evaluate the long term safety and efficacy of VX-770 in subjects with Cystic Fibrosis , protocol number VX08-770-105 PERSIST ACTRN12610000491066

    Study 105 (VX08-770-105) is an open-label, VX-770 treatment extension of Study VX08-770-102 (Study 102) and Study VX08-770-103 (Study 103). This rollover study evaluates the long-term safety and efficacy of treatment with the experimental drug, VX-770, for a duration of up to 96 weeks. Male and female subjects 6 years and older with cystic fibrosis who have completed Study 102 or 103 without major protocol violations are eligible to enrol. This project is an international, multi-centre trial, with subjects from 70 sites worldwide including Australia, Europe and North America. [Study 102: NCT00909532] [Study 103: NCT00909727]

    • Age:

      > 6 years

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not Specified

    • Number of Visits:

      Not specified

    • Length of Participation:

      up to 96 weeks

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  • OtherEnrolling Location: Australia

    Effect of nebulised saline on lung function and quality of life in patients with CF. , protocol number ACTRN12610000754044

    This study will compare 1. compare different concentrations of hypertonic saline delivered via a new fast nebuliser 2. determine whether hypertonic saline is tolerable when delivered via a new fast nebuliser 3. Compare the response to hypertonic saline of patients with badly affected lungs to those patients with mild-moderately affected lungs.

    • Age:

      > 6 years

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not Specified

    • Number of Visits:

      Not specified

    • Length of Participation:

      Not Specified

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  • OtherNot yet recruiting Location: NSW - Australia

    Randomised trial of positive expiratory pressure (PEP) to improve deposition in participants with CF. , protocol number ACTRN12612000017820

    Study aims to determine whether the addition of PEP improves the uniformity of deposition of inhaled aerosol in CF patients. Deposition scan following radioaerosol inhalation with and without PEP will be analysed and compared to data from healthy participants.

    • Age:

      >18 years

    • Mutation(s):

      Not Specified

    • FEV1% Predicted:

      Not Specified

    • Number of Visits:

      Not specified

    • Length of Participation:

      Not Specified

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  • Nutritional-GINot yet recruiting Location: QLD Australia

    The effect of withdrawal of oral iron supplementation on airway microbiology and outcomes in cystic fibrosis. , protocol number ACTRN12612000146897

    An open-label study to examine the effects of withdrawal of oral iron supplements on airway iron content and microbiology in patients with CF.

    • Age:

      18 -70 Years

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not Specified

    • Number of Visits:

      Not specified

    • Length of Participation:

      Not Specified

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  • OtherEnrolling Location: NSW AUSTRALIA

    Prevalence of hypoglycaemia and the role of incretins and glucagon during extended oral glucose tolerance test in people with Cystic Fibrosis. , protocol number ACTRN12616001175460

    This study aims to identify the prevalence of hypoglycaemia during extended OGTT's and associations with biochemical parameters relevant to glucose metabolism. In particular, this study will explore the role of glucagon and the incretions GLP-1 and GIP in reactive hypoglycaemia during OGT's.

    • Age:

      18-45 Years

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      0

    • Length of Participation:

      Not specified

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  • OtherEnrolling Location: NSW - Australia

    Is inhaled tobramycin as effective as intravenous tobramycin and potentially less toxic for treating acute exacerbations of lung infection in those patients with cystic fibrosis (CF) who are chronically colonised with Pseudomonas aeruginosa? , protocol number ACTRN12609000016235

    This study hopes to show that when tobramycin is given via inhalation in those cystic fibrosis patients sick enough to need intravenous (into a vein) antibiotics, the levels in the lung are adequate for effective bacteria elimination and they recover from acute infection. The study will be undertaken in all eligible patients admitted to hospital for treatment of an exacerbation of their lung infection.

    • Age:

      6 Years and older

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      0

    • Length of Participation:

      Not specified

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  • OtherEnrolling Location: NSW - Australia

    An International, Multicenter, Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Mixture Formulation Consisting of Liposomal and Free Ciprofloxacin for inhalation Compared with Placebo for inhalation in the Management of Pseudomonas aeruginosa in Patients with Non-Cystic Fibrosis Bronchiectasis with Chronic Lung infections. , protocol number NCT01515007 ACTRN12609000578202

    This study will compare the safety and efficacy of the mixture formulation consisting of liposomal and free ciprofloxacin for inhalation to placebo for inhalation in patients who have confirmed diagnosis of non-CF bronchiectasis with a history of chronic Pseudomonas Aeruginosa infections.

    • Age:

      18 Years to 80 Years

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      0

    • Length of Participation:

      Not specified

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  • OtherEnrolling Location: NSW - Australia

    A phase 1/11 randomised, placebo-controlled, double blind trial to assess the safety, tolerability, pharmacodynamics and exploratory efficacy inhalation in patients with cystic fibrosis (CF). , protocol number ACTRN12610000328077

    The clinical trial is to assess the safety and tolerability and to explore the efficacy of orally inhaled heparin in patients with cystic fibrosis (CF). Heparin is expected to provide advantages over currently available treatments for CF in a convenient delivery system.

    • Age:

      16 Years

    • Mutation(s):

      Not specified

    • FEV1% Predicted:

      Not specified

    • Number of Visits:

      0

    • Length of Participation:

      Not specified

    Contact us about this clinical Trial >
  • Displaying results 51-60 (of 172)
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