Cystic Fibrosis organisations in Australia provide support and services to people with Cystic Fibrosis (CF) and their carers and families. This is complemented by a commitment to research and a quality improvement program focussing on improved clinical care for people with CF.
Every four days a baby is born in Australia with cystic fibrosis (CF) and more than one million Australians are carriers of cystic fibrosis. Cystic Fibrosis Australia (CFA) is committed to improving clinical practice and patient outcomes through its quality improvement programmes and research with the aim of extending life expectancy from 37 to 50 years by 2025.
Cystic Fibrosis is a recessive genetic condition. It primarily affects the lungs and digestive system because of a malfunction in the exocrine system, responsible for producing saliva, sweat, tears and mucus.
In addition to working for a cure, Cystic Fibrosis Australia also provides support and advocacy to improve the lives of people with cystic fibrosis. Get involved by raising awareness about CF, participating in a fundraising event or volunteering.
Cystic Fibrosis Australia has established a consistent approach to advocacy across Australia and is now a subject matter expert for government, industry and the media.
The Australian Cystic Fibrosis Research Trust (ACFRT) is managed by Cystic Fibrosis Australia (CFA). Since 1989 it has funded more than 300 projects valued at over $6,000,000.
Visit the media room to browse through number of resources including media representatives, press releases and reports.
Clinical trials are listed below.
Location: Multiple care centres across the US
Phase 2 study of LAU-7b in adults with CF (APPLAUD)
, protocol number NCT03265288
This study is taking place at multiple care centers across the U.S. It will look at the safety and effectiveness of the anti-inflammatory drug LAU-7b and it will use a placebo control.
12 years and older
No mutation requirement
Number of Visits:
Length of Participation:
Anti-InfectiveCompleted with results
OPTIMIZE: Phase 3 study of tobramycin solution for inhalation with and without azithromycin
, protocol number NCT02054156 OPTIMIZE-IP-12
This study is taking place at multiple care centers across the US. It will compare the effects of treatment with tobramycin solution for inhalation with and without azithromycin. It is for people with CF who have their first isolation of Pseudomonas aeruginosa from a respiratory culture.
6 Months to 18 Years
No Mutation Requirement
No FEV1 limit
Restore CFTR FunctionCompleted with results
Phase 1b safety study of QR-010 in adults with CF
, protocol number NCT02532764 PRO QR PQ-010-001
This study evaluated the safety and tolerability of the inhaled drug eluforsen in people with CF who have two copies of the F508del CFTR mutation.
18 Years and to 60 Years
Two copies F508del
70% or greater
ObservationalCompleted with results
, protocol number PROSPECT-OB-14
This two-part study is taking place at multiple care centres across the US. It will aim to identify biomarkers that show CFTR function and disease progression. It will also look at the effect of lumacafter/ivacaftor on those who are prescribed treatment.
6 Years and Older
No FEV1 Limit
Mucociliary ClearanceClosed to enrollment
Clearing Lungs With ENAC Inhibition in Cystic Fibrosis (CLEAN-CF)
, protocol number Parion PS-G201
This trail will look at the safety of the drug P-1037 and its effectiveness in combination with the drug hypertonic saline. The trail is estimated to last 5 weeks. It is for people with CF age 12 years and older.
12 Years and Older
40 to 90%
AeroVanc for the treatment of MRSA in people with CF
, protocol number Savara SAV005-02 NCT01746095
This study evaluated the safety and effectiveness of AeroVanc in treating persistent MRSA lung infections in people with cystic fibrosis.
30 to 100%
Mucociliary ClearanceCompleted with results
SHIP: Study of hypertonic saline in preschoolers
, protocol number NCT02378467 SHIP01
This SHIP study evaluated the safety and effectiveness of hypertonic saline (7%) in pre-school children with CF.
3 Years to 5 Years
Less than 99%
Anti-InflammatoryCompleted with results
Phase 2 Study of inhaled Alpha-1 HC in people with CF
, protocol number Grifols T6005-201
This study took place at multiple care centres across the US. It looked at the safety and tolerability of inhaled Alpha-1 HC administered once a day for three weeks in people with CF.
18 Years and Older
Phase 2 Study of Inhaled Nitric Oxide in People with CF
, protocol number NCT02498535
This study is taking place at multiple care centres across the US. It will look at the effectiveness of the inhaled drug nitric oxide in adults with cystic fibrosis who are taking an inhaled antibiotic.
18 years and older
Nutritional-GICompleted with results
Phase 2 study of oral glutathione in children with cystic fibrosis.
, protocol number GROW-IP-16 NCT03020719
This study evaluated the safety and effectiveness of the oral drug glutathione in children with cystic fibrosis who use pancreatic enzyme replacement therapy (PERT).
24 months - 10 years