SPI-1005 is an oral form of the drug ebselen. Ebselen is a molecule designed to mimic the function of a key enzyme found in the inner ear, glutathione peroxidase (GPx). Regular use of aminoglycoside antibiotics can cause damaging side effects in the inner ear. By mimicking the function of GPx, SPI-1005 may protect the inner ear from damage.
A phase 2 study to test the safety and tolerability of SPI-1005 in people with CF is currently underway.
This program is sponsored by Sound Pharmaceuticals and partially funded by the Cystic Fibrosis Foundation.
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