Lives unaffected by cystic fibrosis


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PTI-808 (alone & in combination)

Phase Two

Phase Two

Therapeutic Approach

Restore CFTR Function

PTI-808 is a type of CFTR modulator called a potentiator. Potentiators help facilitate the opening of the chloride channel on the cell surface to allow chloride and sodium (salt) to move in and out of the cell.


A phase 1 study to test the safety and tolerability of PTI-808 in healthy adults is underway.


This program is sponsored by Proteostasis Therapeutics. It is being conducted through the Therapeutics Development Network.

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