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Dornase Alpha (Pulmozyme®)

To Patients

To Patients

Therapeutic Approach

Mucociliary Clearance

Dornase alfa (Pulmozyme®) is an inhaled medication that thins and loosens mucus in the airways of people with CF.


A Phase 3 clinical trial showed improvement in lung function and reduction in pulmonary exacerbations. It was approved for use by the FDA in 1993.

In Australia, dornase alfa 2.5mg/2.5ml (inhalation solution) is approved by the TGA and listed for reimbursement on the PBS.


In  the US, the program was sponsored by Genentech, Inc and the Cystic Fibrosis Foundation.


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