DRUG DEVELOPMENT PIPELINE

Restore CFTR Function

• Pre-clinical
• Phase One
• Phase Two
• Phase Three
• To Patients

• KALYDECO® (Ivacaftor)   › : To Patients   ›
• ORKAMBI® (Lumacaftor + ivacaftor)   › : To Patients   ›
• SYMDEKO™ (Tezacaftor (VX-661) + ivacaftor   › : To Patients   ›
• Elexacaftor + tezacaftor + ivacaftor (Trikafta™)   › : To Patients   ›
• ELX-02   › : Phase Two   ›
• ABBV-2222 (formerly GLPG2222)   › : Phase Two   ›
• PTI-428 + PTI-801 + PTI-808   › : Phase Two   ›
• VX-561 (formerlly CTP-656 - Deuterated ivacaftor)   › : Phase Two   ›
• VX-121   › : Phase Two   ›
• ABBV-3067   › : Phase Two   ›
• MRT5005   › : Phase One   ›
• Arcturus   › : Pre-clinical   ›
• Icagen   › : Pre-clinical   ›
• ReCode Therapeutics   › : Pre-clinical   ›
• Southern Research Institute   › : Pre-clinical   ›
• Spirovant Sciences   › : Pre-clinical   ›
• 4D Molecular Therapeutics   › : Pre-clinical   ›
• Editas   › : Pre-clinical   ›
• Genzyme/Sanofi   › : Pre-clinical   ›
• Pfizer   › : Pre-clinical   ›
• Reata   › : Pre-clinical   ›
• AbbVie   › : Pre-clinical   ›

• Mucociliary Clearance

  • Pre-clinical
  • Phase One
  • Phase Two
  • Phase Three
  • To Patients

  • Inhaled Mannitol (Bronchitol®)   › : To Patients   ›
  • Dornase Alpha (Pulmozyme®)   › : To Patients   ›
  • Hypertonic Saline   › : To Patients   ›
  • BI 1265162   › : Phase Two   ›
  • OligoG   › : Phase Two   ›
  • AZD5634   › : Phase One   ›
  • ETD002   › : Phase One   ›
  • Ionis-ENaC-2.5Rx   › : Pre-clinical   ›

• Anti-Inflammatory

  • Pre-clinical
  • Phase One
  • Phase Two
  • Phase Three
  • To Patients

  • Ibuprofen   › : To Patients   ›
  • Lenabasum (JBT-101)   › : Phase Two   ›
  • LAU-7b   › : Phase Two   ›
  • Lonodelestat (formerly POL6014)   › : Phase One   ›
  • CB-280   › : Phase One   ›

• Anti-Infective

  • Pre-clinical
  • Phase One
  • Phase Two
  • Phase Three
  • To Patients

  • Azithromycin   › : To Patients   ›
  • Aztreonam (Cayston®)   › : To Patients   ›
  • Inhaled Tobramycin   › : To Patients   ›
  • Tobramycin Inhaled Powder (TOBI® Podhaler™)   › : To Patients   ›
  • Inhaled Levofloxacin   › : Phase Three   ›
  • Vancomycin Inhalation Powder (AeroVanc™)   › : Phase Three   ›
  • Nitric Oxide (Inhaled)   › : Phase Two   ›
  • Intravenous Gallium   › : Phase Two   ›
  • SPI-1005   › : Phase Two   ›
  • AP-PA02   › : Phase Two   ›
  • ALX-009   › : Phase One   ›
  • SNSP113   › : Phase One   ›
  • Gallium (Inhaled)   › : Phase One   ›
  • Microbion   › : Pre-clinical   ›
  • Respirion   › : Pre-clinical   ›
  • TB Alliance   › : Pre-clinical   ›

• Nutritional-GI

  • Pre-clinical
  • Phase One
  • Phase Two
  • Phase Three
  • To Patients

  • RELiZORB®   › : To Patients   ›
  • AquADEKs   › : To Patients   ›
  • Pancrelipase Enzyme Products   › : To Patients   ›
  • MS1819-SD   › : Phase Two   ›
  • Synspira   › : Pre-clinical   ›

CF Lives Matters is a collaboration between Cystic Fibrosis Australia and the Cystic Fibrosis Foundation and we thank them for their support.