Lives unaffected by cystic fibrosis

Bones (muscular skeletal)

Bone disease is a common complication of cystic fibrosis (CF). The cause of this is multifactorial, many reasons can contribute/cause bone disease in CF. Osteopenia is a condition when the bones become more brittle and weak; it can often lead to osteoporosis, and the bones are at more risk of breaking (fractures).

CF nutritional issues can affect the development of bones and muscles. Lower levels of physical activity, particularly weight bearing exercises, may also affect the development of bone strength and the maintenance of bone health.

CF bone disease can have a significant impact on lifestyle and quality of life. Consequences of bone disease can include limited mobility and function, pain, and increased burden of care. Bone disease may also limit involvement in certain physical activities for example contact sport or activities that may place the person at a higher risk of injury. This can have a direct impact or influence on mental health well-being.

Osteoporosis and osteopenia can happen at any age. It is more common in the late teens and in adults in people with CF.

New research is suggesting that the co-morbidities of CF in this area branch out even further than previously expected. For example, the use of estrogen-based birth control pills could be a factor in decreased bone density for women living with CF.

People living with CF often also have difficulty absorbing vitamin D, which is an additional risk factor for developing osteopenia.

CF and Bone/Muscle Health:

https://www.cysticfibrosisjournal.com/article/S1569-1993(17)30032-2/fulltext

https://cysticfibrosisnewstoday.com/2019/08/19/nebraskas-neena-nizar-seeks-cure-for-jansens-one-of-worlds-rarest-diseases/

https://cysticfibrosisnewstoday.com/2020/04/28/estrogen-birth-control-pills-could-lessen-bone-density-in-cf-study/

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30028-4/fulltext

https://www.cff.org/Life-With-CF/Daily-Life/Fitness-and-Nutrition/Nutrition/Protecting-and-Maintaining-Bone-Health/Bone-Disease-and-CF/